1 Samuel 5:6

But the hand of the Lord was heavy upon the Ashdodites, etc. Those who, having taken up the ark of God, grieve for Dagon's destruction and set up his ruin, are struck in their hind parts, and their land is ravaged by mice. For those who, having been taught the recognition of faith or even mysteries, either do not endure the idols to be cast down, or allow themselves to be forbidden from vices, because they look back, do not abandon the uncleanness of their old life, and reclaim those things which they ought to have forgotten and regarded as dung, as the Apostle says (Philippians 3). They are punished by the things they choose, and that becomes the cause of punishment to the wretched, which was the pleasure of their guilt. But even if they seem to produce any good, those who keep the eyes of their mind turned backwards, the root of their thought and the fruit of their action are destroyed by unclean spirits. The Lord struck not only Ashdod where Dagon was, but all the borders of Ashdod because he condemns and rejects not only the capital crimes in which the manifest work of the devil is evident, but also the small ones which appear minor or light sins to men, by the sentence of the strict judge. Ultimately, every idle word that men shall speak, they shall give account thereof in the day of judgment (Matthew 12).

5. The hand of the Lord is the power of divine might. And because in the Azotians the beginnings of paganism are signified, what does it mean that the hand of the Lord is said to have been made heavy upon the Azotians? But He made His hand heavy upon Azotus when He moved the hearts of the Gentiles to conversion by the power of His might. For when through inward inspiration He made known to them the force of eternal death, He struck the minds of the Gentiles with wondrous terror over the iniquities they had committed. Therefore, since when the hand of the Lord is said to be made heavy, the Azotians are said to be slain, this heaviness of the hand is understood as the multiplication of the converted. For to die, for the Gentiles, was to be separated from unbelief. Likewise, to be slain by the hand of the Lord is to obtain that same knowledge of the true faith not through the ministry of men but by divine power. The hand of the Lord was therefore light upon Azotus when as yet, through a few ministers of the faith, only a few were abandoning the error of paganism. Hence the Lord also urges the ministers of the word to pray, as if concerning the making heavy of His hand, saying: 'The harvest indeed is great, but the laborers are few: pray the Lord of the harvest to send laborers into His harvest' (Matt. 9:38). As if He were saying in other words: He who through a few ministers, as if with a light hand, separates a few from unbelief — pray that He multiply the ministers, so that He may, as it were, make His hand heavy in the multitude of the converted. But the manner of the slaying is also explained: for whoever is said to die by this slaying, while going out to purge his bowels, is said to be bitten by mice in the more hidden part of the buttocks. According to the letter, one single striking is shown here, but in the typological exposition it is doubled. For by the signification of the letter, both the making heavy of the Lord's hand and the biting of the mice pertain to the effect of the same death: because the hand of the Lord is said to be made heavy upon the Azotians for this reason — that they are slain by the biting of the mice. 6. But because through spiritual signification we have recognized two deaths—one, namely, by which sinners die to righteousness by sinning, and the other by which the righteous raise themselves from the sins in which they had lived…