Strong's Exhaustive Concordance (James Strong, 1890/1894), public domain; digitized by Open Scriptures (CC BY-SA). KJV word tagging: eBible.org (public domain). Original-language text, parsing and brief lexicon: STEPBible.org data from Tyndale House, Cambridge (CC BY 4.0).
Cross-references
Philemon 1:25 The grace of our Lord Jesus Christ be with your spirit. Amen.
Galatians 6:18 Brethren, the grace of our Lord Jesus Christ be with your spirit. Amen.
Colossians 4:18 The salutation by the hand of me Paul. Remember my bonds. Grace be with you. Amen.
Romans 1:7 To all that be in Rome, beloved of God, called to be saints: Grace to you and peace from God our Father, and the Lord Jesus Christ.
Ephesians 6:24 Grace be with all them that love our Lord Jesus Christ in sincerity. Amen.
1 Peter 5:14 Greet ye one another with a kiss of charity. Peace be with you all that are in Christ Jesus. Amen.
Revelation 22:21 The grace of our Lord Jesus Christ be with you all. Amen.
Matthew 28:20 Teaching them to observe all things whatsoever I have commanded you: and, lo, I am with you alway, even unto the end of the world. Amen.
Cross-references from OpenBible.info (CC BY), in the lineage of the Treasury of Scripture Knowledge (public domain).
Commentary
Matthew Henry on 2 Timothy 4:16–end
Here, I. He gives Timothy an account of his own present circumstances.
1. He had lately been called to appear before the emperor, upon his appeal to Caesar; and then no man stood with him (Ti2 4:16), to plead his cause, to bear testimony for him, or so much as to keep him in countenance, but all men forsook him. This was strange, that so good a man as Paul should have nobody to own him, even at Rome, where there were many Christians, whose faith was spoken of throughout the world, Rom 1:8. But men are but men. The Christians at Rome were forward to go and meet him (Acts 28); but when it came to the pinch, and they would be in danger of suffering with him, then they all forsook him. He prays…
Grace be with you--plural in oldest manuscripts, "with YOU," that is, thee and the members of the Ephesian and neighboring churches.
Next: Titus Introduction
Adam Clarke on 2 Timothy 4:22
The Lord Jesus Christ be with thy spirit - This is a prayer addressed to Christ by one of the most eminent of his apostles; another proof of the untruth of the assertion, that prayer is never offered to Christ in the New Testament. He prays that Christ may be with his spirit, enlightening, strengthening, and confirming it to the end.
Grace be with you - These words show that the epistle was addressed to the whole Church, and that it is not to be considered of a private nature.
Amen - Omitted by ACFG and some others. See the note on this word at the end of the preceding epistle (note).
The principal subscriptions, both in the versions and MSS., are the following: -
The Second Epistle to Timo…
The Lord Jesus Christ be with thy spirit,.... To counsel and advise in every difficult matter; to comfort under every distress; to supply with all grace in every time of need; and to strengthen and fit for every part and branch of duty.
Grace be with you, Amen: which is the apostle's common salutation in all epistles. The Syriac version renders it, "grace be with thee"; but the Greek copies read in the plural, "with you"; which shows that the epistle was designed for the use of the whole church, as well as of Timothy. The subscription follows, which is not in many ancient copies, and is not to be depended on.
The second epistle unto Timotheus; so far is right; this is certainly the second…
The Church Fathers
"The Lord Jesus Christ be with thy spirit." There can be no better prayer than this. Grieve not for my departure. The Lord will be with thee. And he says, not "with thee," but "with thy spirit." Thus there is a twofold assistance, the grace of the Spirit, and God helping it. And otherwise God will not be with us, if we have not spiritual grace. For if we be deserted by grace, how shall He be with us? "Grace be with us. Amen." Thus he prays for himself too, that they may always be well-pleasing to Him, that they may have grace together with the spiritual gift, for where this is, nothing will be grievous. For as he who beholds the king, and is in favor with him, is sensible of no uneasiness; so though our friends forsake us, though we be overtaken by calamity, we shall feel no distress, if that grace be with us and fortify us.
The Lord Jesus Christ be with your spirit. Grace be with us all. Amen. The Lord Jesus Christ be with your spirit. The help is twofold, that of Christ and that of the Holy Spirit, as if Paul were saying, With the coming of the Holy Spirit which you now have. Let also the Lord Jesus Christ be with you. Since this is with you, you will not suffer at my departure. Or that it is not possible to enjoy the presence of Christ without being endowed with spiritual grace, so as to be, in relation to this interpretation, with your spirit, that is, with spiritual grace. Grace be with us. And Paul prays for himself, either so that he may always be grateful, or so that he may always have a spiritual gift. Finished, with divine help, of the later Epistle to Timothy. It was written from the city of Rome, when Paul was brought before Nero Caesar the Roman for the second time.
The Church Fathers: public-domain translations (Ante-Nicene and Nicene and Post-Nicene Fathers), verse-indexed by SermonIndex (CC BY 4.0).
Dictionary and topics
Roman Empire, The · Emperors of, mentioned: Nero — Emperors of, mentioned: Nero
Dictionary: Easton's (1897) and Smith's (1863), public domain. Topics: Nave's Topical Bible (1896) and Torrey's Topical Textbook (1897), public domain. Both as parsed by NEUU (CC BY 4.0).
14. Alexander the coppersmith did me much evil: the Lord reward him according to his works:
14. Alexander faber aerarius multis me malis affecit: reddat illi Dominus juxta facta ipsius.
15. Of whom be thou ware also; for he hath greatly withstood our words.
15. Quem et tu cave; vehementer enim restitit verbis nostris.
16. At my first answer no man stood with me, but all men forsook me: I pray God that it may not be laid to their charge.
16. In prima defensione nemo mihi affuit, sed omnes me deseruerunt: ne illis imputetur.
17. Notwithstanding the Lord stood with me, and strengthened me; that by me the preaching might be fully known, and that all the Gentiles might hear: and I was deliv…
The precise phrasing here is unique, perhaps to emphasize what had already been said in 1:6-8; 2:1 (cp. Gal 6:18; Phil 4:23; Phlm 1:25). • with all of you: This letter would be read publicly.