Isaiah 65:2

It is the nations who did not have a prophet sent to them who recognize their maker and benefactor, whereas those who received all sorts of care gained no profit but continued in their sinful habits. The phrase "all day long I have held out my hands" refers to the care for them that he gave for all that time, but the saving suffering of the cross in which he stretched out his hands is also alluded to here.

If, dearly beloved, we comprehend faithfully and wisely the beginning of our creation, we shall find that humankind was made in God's image, to the end that he might imitate the Creator and that our race attains its highest natural dignity, by the form of the divine goodness being reflected in us, as in a mirror. And assuredly to this form the Savior's grace is daily restoring us, so long as that which in the first Adam fell, is raised up again in the second. And the cause of our restoration is nothing else but the mercy of God, whom we would not have loved unless he had first loved us and dispelled the darkness of our ignorance by the light of his truth.

(Verse 2) I have stretched out my hands all day long to an unbelieving people, who walk in a way that is not good, following their own thoughts. LXX: I have stretched out my hands all day long to an unbelieving and contradicting people, who have not walked in the good way but after their own sins. This, which is said above, 'I appeared to those who did not ask for me; I was found by those who did not seek me,' the Apostle Paul, writing to the Romans, after he had explained concerning the role of the Gentiles, added: But to Israel he says, 'I have stretched out my hands to an unbelieving and contradicting people' (Rom. 10:21), who, though overcome by the Lord's blessings and witnessing signs beyond human capability, said, 'This man does not cast out demons, except by Beelzebub, the prince of demons' (Luke 11:15). And again: You are a Samaritan and have a demon (John 8:48). And again: Though you are only a man, you make yourself out to be God (John 10:33). And elsewhere: This man is not from God, for he does not keep the Sabbath (John 9:10). And many other things that would take too long to tell. Finally, when he stretched out his hands to the unbelieving people from the cross and said, 'Father, forgive them, for they do not know what they are doing' (Luke 23:34), those nearby said, 'Bah!' He who destroys the Temple, and in three days builds it up again: let him come down now from the cross, and we will believe him. He saved others, himself he cannot save. (Matt. XXVII, 40) . And Simeon, taking the child in his arms, prophesied about him: Behold, this child is set for the fall and rising again of many in Israel, and for a sign which shall be spoken against. (Luke II, 34) . In Rome, the Jews speak to Paul: We have heard of this sect, that everywhere it is spoken against. (Acts XXVIII, 41) . We can extend our hands and receive in the generosity of the giver, because he denies nothing to those who ask: but immediately restores health to the leper when he asks (Matth. VIII): and receives eyes to the blind man from birth (John. IX): and the hungry, apart from children and women, were satisfied with thousands of people in the desert (Matth. XIV). They signify extended hands and the mercy of a parent who eagerly receives their children into their embrace. Those who walked in the wrong way and followed their own thoughts. To them the Lord speaks through the Prophet:…